منابع مشابه
When sparks get old
Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca2+ signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that the Ca2+ response to osmotic stress is substantially altered in aged muscle. The study presents evi...
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Aging is a nearly universal phenomenon in biology only partially controlled by genetic endowment. Individuals and their organs age at varying rates. The kidneys manifest the aging process by steady loss of nephrons and a corresponding decrease in glomerular filtration rate (GFR) beginning about age 30 years. The mechanisms responsible for this observation is are elusive. However, defining chron...
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Cellular senescence, even in the presence of abundant nutrients, has now been demonstrated in several microbes, including most recently the bacterium Escherichia coli, suggesting that it may be a universal adaptive response to the inevitable damage to cell constituents that accumulates with time.
متن کاملWhen GET Got Noticed: The Emerging Salience of GET-Passives
Recent research on the use of the get-passive has suggested that it is rising in frequency at the expense of the be-passive both in spoken American English (Weiner & Labov 1983, Herold 1986, Kim 2012) and spoken British English (Collins 1996, Carter & McCarthy 1999, Kim 2012). Accounts of the variability between get and be have appealed to pragmatic and grammatical factors (Lakoff 1971, Chappel...
متن کاملAcute inflammatory arthritis in the elderly; Old flames, new sparks.
BACKGROUND The overall world prevalence of rheumatoid arthritis (RA) ranges from 0.5-1.0%. The annual incidence of RA in most European countries ranges from roughly 0.4 to >2.5 per 1,000 adults, increasing with age. A significant proportion of newly diagnosed cases will evolve into true erosive RA. METHODS The aim of this cohort study was to study the characteristics of new developing, acute ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200608014